Prokaryotic NAT genes(a)

 

 

Original List (2013)

 

For additional NAT genes annotated in prokaryotes, see here

 

 

 

Organism scientific name (b)

 

Organism identification code (b)

Taxonomy identifier (b)

Gene (c)

ORF (bp) (d)

Protein (aa)

(d)

Identities

(%) (e)

Positives

(%) (e)

Known enzyme

activity/structure?

Literature

ARCHAEA

Halogeometricum borinquense, strain DSM 11551

HALBP (DSM 11551)

469382

NAT1

786

261

28

43

No

33, BN001449

BACTERIA

ACTINOBACTERIA

Amycolatopsis mediterranei

AMYMD

33910

NAT/rifF

783

260

26

40

Yes

1-6

Brevibacterium linens BL2

BRELN (BL2)

321955

NAT1

870

289

29

48

No

1

Frankia sp. EAN1pec

FRASN

298653

NAT1

807

268

28

45

No

1

Janibacter sp. HTCC 2649

 

313589

NAT1

876

291

35

51

No

1

Mycobacterium avium 104

MYCA1

243243

NAT1

831

276

37

53

No

1,2,7

Mycobacterium avium subsp. paratuberculosis K-10

MYCPA (K-10)

262316

NAT1

831

276

37

53

No

1,2,8

Mycobacterium bovis AF2122/97

MYCBO (AF2122/97)

233413

NAT1

852

283

34

52

No

1,2,7

Mycobacterium bovis BCG str. Pasteur 1173P2

MYCBP

410289

NAT1

852

283

34

52

Yes

1,2,9-11

Mycobacterium gilvum PYR-GCK

MYCGI

350054

NAT1

828

275

35

53

No

1

Mycobacterium intracellulare ATCC 13950

MYCIT (ATCC 13950)

487521

NAT1

831

276

37

52

No

1

Mycobacterium marinum M

MYCMM

216594

NAT1

843

280

36

52

Yes

1,12

Mycobacterium smegmatis str. MC2 155

MYCS2

246196

NAT1

828

275

34

51

Yes

1,2,7,8,13-16

Mycobacterium sp. JLS

MYCSJ

164757

NAT1

846

281

36

54

No

1

Mycobacterium sp. KMS

MYCSK

189918

NAT1

846

281

36

54

No

1

Mycobacterium sp. MCS

MYCSS

164756

NAT1

846

281

36

54

No

1

Mycobacterium tuberculosis C

MYCTU (C)

348776

NAT1

852

283

34

52

No

1

Mycobacterium tuberculosis CDC1551

MYCTU (CDC1551)

83331

NAT1

852

283

34

52

No

1,2

Mycobacterium tuberculosis F11

MYCTF

336982

NAT1

852

283

34

52

No

1

Mycobacterium tuberculosis H37Ra

MYCTA

419947

NAT1

852

283

34

52

No

1

Mycobacterium tuberculosis H37Rv

MYCTU (H37Rv)

83332

NAT1

852

283

34

52

Yes

1,2,7-9,13

Mycobacterium tuberculosis str. Haarlem

MYCTU (Haarlem)

395095

NAT1

852

283

34

52

No

1

Mycobacterium tuberculosis KZN 1435

MYCTU (KZN 1435)

478434

NAT1

852

283

34

52

No

1

Mycobacterium tuberculosis KZN 4207

MYCTU (KZN 4207)

478433

NAT1

852

283

34

52

No

1

Mycobacterium tuberculosis KZN 605

MYCTU (KZN 605)

478435

NAT1

852

283

34

52

No

1

Mycobacterium ulcerans Agy99

MYCUA

362242

NAT1

843

280

36

52

No

1

Mycobacterium vanbaalenii PYR-1

MYCVP

350058

NAT1

837

278

36

55

No

1

Nocardia farcinica IFM 10152

NOCFA (IFM 10152)

247156

NAT1

882

293

35

48

No

1,2,34

Rhodococcus sp. RHA1

RHOSR

101510

NAT1

825

274

36

51

Yes

1,17

Saccharopolyspora erythraea NRRL 2338

SACEN

405948

NAT1

858

285

33

49

No

1

Salinispora arenicola CNS-205

SALAI

391037

NAT1

777

258

32

49

No

1

Streptomyces avermitilis MA-4680

STRAW (MA-4680)

227882

NAT1

840

279

31

46

No

1,2,8

Streptomyces griseus subsp. griseus NBRC13350

STRGG

455632

 

NAT1

813

270

34

47

Yes

1,18

NAT2

810

269

32

45

BACTEROIDETES / CHLOROBI

Chlorobium ferrooxidans DSM 13031

 

377431

NAT1

795

264

29

51

No

1

Chlorobium limicola DSM 245

CHLL2

290315

NAT1

774

257

31

49

No

1

Chlorobium phaeobacteroides DSM 266

CHLPD

290317

NAT1

774

257

30

48

No

1

Microscilla marina ATCC 23134

 

313606

NAT1

798

265

32

48

No

1

Pelodictyon phaeoclathratiforme BU-1

 

324925

NAT1

675

224

30

50

No

1

Prosthecochloris aestuarii DSM 271

PROAE (DSM 271)

290512

NAT1

681

226

31

51

No

1

CYANOBACTERIA

Lyngbya sp. PCC 8106

 

313612

NAT1

759

252

32

51

No

1

Synechococcus sp. JA-2-3B’a(2-13)

SYNJB

321332

NAT1

915

304

34

51

No

1

FIRMICUTES

Bacillales

Bacillus amyloliquefaciens FZB42

BACA2

326423

NAT1

747

248

27

44

No

1

Bacillus anthracis Tsiankovskii-I

BACAN (Tsiankovskii-I)

405536

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. “Ames Ancestor”

BACAN (Ames Ancestor)

261594

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. A1055

BACAN (A1055)

280355

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

792

263

29

49

Bacillus anthracis str. A2012

BACAN (A2012)

191218

NAT1

840

279

27

44

No

1,2

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. A0174

BACAN (A0174)

486622

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3(f)

792

263

29

49

Bacillus anthracis str. A0193

BACAN (A0193)

486619

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3(f)

792

263

29

49

Bacillus anthracis str. A0389

BACAN (A0389)

486623

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3(f)

792

263

29

49

Bacillus anthracis str. A0442

BACAN (A0442)

486621

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

792

263

29

49

Bacillus anthracis str. A0465

BACAN (A0465)

486620

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

792

263

29

49

Bacillus anthracis str. A0488

BACAN (A0488)

486624

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3(f)

792

263

29

49

Bacillus anthracis str. Ames

BACAN (Ames)

198094

NAT1

840

279

27

44

No

1,2,7,8

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. Australia 94

BACAN (Australia 94)

280477

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. CNEVA-9066

BACAN (CNEVA-9066)

280354

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

792

263

29

49

Bacillus anthracis str. Kruger B

BACAN (Kruger B)

205919

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

792

263

29

49

Bacillus anthracis str. Sterne

BACAN (Sterne)

260799

NAT1

840

279

27

44

Yes

1,2,19,20

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. Vollum

BACAN (Vollum)

261591

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus anthracis str. Western North America

BACAN (Western North America)

212045

NAT1

840

279

27

44

No

1

NAT2

768

255

26

45

NAT3

654

217

29

49

Bacillus cereus 03BB108

BACCE (03BB108)

451709

NAT1

840

279

27

44

No

1

NAT2

768

255

30

48

NAT3

792

263

29

49

Bacillus cereus AH1134

BACCE (AH1134)

405533

NAT1

840

279

28

44

No

1

NAT2

768

255

32

51

NAT3

792

263

29

48

Bacillus cereus AH187

BACCE (AH187)

405534

NAT1

840

279

27

44

No

1

NAT2

768

255

31

50

NAT3

792

263

30

48

Bacillus cereus AH820

BACCE (AH820)

405535

NAT1

840

279

27

44

No

1

NAT2

768

255

31

49

NAT3

792

263

29

49

Bacillus cereus ATCC 10987

BACC1

222523

NAT1

840

279

26

45

No

1,2,8

NAT2

768

255

31

49

NAT3

792

263

29

48

Bacillus cereus ATCC 14579

BACCR

226900

NAT1

840

279

27

44

No

1,2,8

NAT2

768

255

32

50

NAT3

792

263

29

48

Bacillus cereus B4264

BACCE (B4264)

405532

NAT1

840

279

28

44

No

1

NAT2

768

255

32

51

NAT3

792

263

29

48

Bacillus cereus ZK/E33L

BACCZ

288681

NAT1

840

279

26

44

No

1,2

NAT2

768

255

29

48

NAT3

792

263

29

48

Bacillus cereus G9241

BACCE (G9241)

269801

NAT1

840

279

27

44

No

1,2

NAT2

768

255

29

48

NAT3

792

263

26

43

Bacillus cereus G9842

BACCE (G9842)

405531

NAT1

840

279

27

44

No

1

NAT2

768

255

31

50

NAT3

792

263

29

48

Bacillus cereus H3081.97

BACCE (H3081.97)

451708

NAT1

840

279

27

44

No

1

NAT2

768

255

31

50

NAT3

792

263

30

48

Bacillus cereus NVH0597-99

BACCE (NVH0597-99)

451707

NAT1

840

279

27

44

No

1

NAT2

768

255

27

46

NAT3

792

263

29

49

Bacillus cereus W

BACCE (W)

405917

NAT1

840

279

27

44

No

1

NAT2

768

255

31

49

NAT3

792

263

30

49

Bacillus cereus subsp. cytotoxis NVH 391-98

BACCN

315749

NAT1

792

263

29

50

No

1

Bacillus clausii KSM-K16

BACSK

66692

NAT1

813

270

32

45

No

1

Bacillus coahuilensis m4-4

 

441769

NAT1

822

273

26

48

No

1

Bacillus halodurans C-125

BACHD

272558

NAT1

831

276

27

45

No

1,2,21

Bacillus licheniformis DSM 13/ATCC 14580

BACLD

279010

NAT1

759

252

28

43

No

1,2

Bacillus pumilus SAFR-032

BACP2

315750

NAT1

747

248

25

42

No

1

Bacillus sp. NRRL B-14911

BACSP (NRRL B-14911)

313627

NAT1

741

246

30

51

No

1

Bacillus subtilis subsp. subtilis str. 168

BACSU (subtilis 168)

224308

NAT1

765

254

28

47

No

1,2,7,8

Bacillus thuringiensis serovar israelensis ATCC 35646

BACTU (israelensis ATCC 35646)

439028

NAT1

840

279

27

44

No

1

NAT2

807

268

24

43

Bacillus thuringiensis serovar konkukian str. 97-27

BACHK (97-27)

281309

NAT1

840

279

26

44

No

1,2,8

NAT2

768

255

31

48

NAT3

792

263

26

43

Bacillus thuringiensis str. Al Hakam

BACAH

412694

NAT1

840

279

27

44

No

1

NAT2

768

255

32

50

NAT3

792

263

29

48

Bacillus weihenstephanensis KBAB4

BACWK

315730

NAT2

768

255

31

50

No

1

NAT3

792

263

28

48

Exiguobacterium sibiricum 255-15

EXIS2

262543

NAT1

792

263

28

46

No

1,2

Staphylococcus aureus RF122

STAAB

273036

NAT1

819

272

25

44

No

1

Staphylococcus aureus subsp. aureus COL

STAAC

93062

NAT1

801

266

27

46

No

1,7

Staphylococcus aureus subsp. aureus JH1

STAA2

359787

NAT1

801

266

27

46

No

1

Staphylococcus aureus subsp. aureus JH9

STAA9

359786

NAT1

801

266

27

46

No

1

Staphylococcus aureus subsp. aureus MRSA252

STAAR

282458

NAT1

801

266

27

46

No

1,2,8

Staphylococcus aureus subsp. aureus MSSA476

STAAS

282459

NAT1

801

266

26

46

No

1,2,8

Staphylococcus aureus subsp. aureus MW2

STAAW

196620

NAT1

801

266

26

46

No

1,8

Staphylococcus aureus subsp. aureus Mu3

STAA1

418127

NAT1

801

266

27

46

No

1

Staphylococcus aureus subsp. aureus Mu50

STAAM

158878

NAT1

801

266

27

46

No

1,2,8

Staphylococcus aureus subsp. aureus N315

STAAN

158879

NAT1

801

266

27

46

No

1,8

Staphylococcus aureus subsp. aureus NCTC 8325

STAA8

93061

NAT1

801

266

27

46

No

1

Staphylococcus aureus subsp. aureus USA300

STAA3

367830

NAT1

801

266

27

46

No

1

Staphylococcus aureus subsp. aureus USA300_TCH1516

STAAT

451516

NAT1

795

264

27

46

No

1

Staphylococcus aureus subsp. aureus str. Newman

STAAE

426430

NAT1

801

266

27

46

No

1

Staphylococcus epidermidis ATCC 12228

STAES

176280

NAT1

786

261

28

45

No

1,2,8

Staphylococcus epidermidis RP62A

STAEQ

176279

NAT1

786

261

28

44

No

1

Staphylococcus haemolyticus JCSC1435

STAHJ

279808

NAT1

786

261

27

46

No

1

Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

STAS1

342451

NAT1

780

259

25

48

No

1

Clostridia

Desulfitobacterium hafniense DCB-2

DESHD

272564

NAT1

801

266

32

48

No

1,2

Desulfitobacterium hafniense Y51

DESHY

138119

NAT1

801

266

32

47

No

1

Lactobacillales

Lactococcus lactis subsp. cremoris MG1363

LACLM

416870

NAT1

804

267

30

48

No

1

PROTEOBACTERIA

Alpha-proteobacteria

Rhizobiaceae

Rhizobium etli CFN 42

RHIEC

347834

NAT1

792

263

30

45

No

1

Rhizobium etli CFN 42 plasmid p42e

RHIEC (plasmid p42e)

347834

NAT1A

846

281

30

45

No

1

Other alpha-proteobacteria

Bradyrhizobium sp. ORS278

BRASO

114615

NAT1

816

271

35

51

No

1

NAT2

816

271

35

52

Bradyrhizobium sp. BTAi1

BRASB

288000

NAT1

816

271

36

50

No

1

NAT2

816

271

36

54

Caulobacter sp. K31

CAUSK

366602

NAT1

876

291

40

52

No

1

Caulobacter crescentus CB15

CAUCR (CB15)

190650

NAT1

828

275

37

53

No

1,2,7,8

Labrenzia (Stappia) aggregata IAM 12614

 

384765

NAT1

813

270

31

48

No

1

Mesorhizobium loti MAFF303099

RHILO (MAFF303099)

266835

NAT1

837

278

37

54

Yes

1,2,8,21-25

NAT2

813

270

39

54

Novosphingobium aromaticivorans DSM 12444

NOVAD

279238

NAT1

846

281

36

48

No

1,2,21

NAT2

882

293

26

41

Parvibaculum lavamentivorans DS-1

PARL1

402881

NAT1

837

278

35

55

No

1

Rhodobacterales bacterium HTCC2654

 

314271

NAT1

816

271

33

50

No

1

Sphingopyxis alaskensis RB2256

SPHAL (RB2256)

317655

NAT1

879

292

39

56

No

1

Sphingomonas wittichii RW1

SPHWW

392499

NAT1

1131

376

37

49

No

1

Beta-proteobacteria

Burkholderiaceae

Burkholderia ambifaria AMMD

BURCM

339670

NAT1

834

277

38

52

No

1,2

Burkholderia ambifaria MC40-6

BURA4

398577

NAT1

834

277

42

59

No

1,2

Burkholderia cenocepacia AU 1054

BURCA

331271

NAT1

831

276

42

58

No

1

Burkholderia cenocepacia HI2424

BURCH

331272

NAT1

831

276

42

58

No

1

Burkholderia cenocepacia MC0-3

BURCC

406425

NAT1

831

276

42

58

No

1

Burkholderia cenocepacia PC184

 

350702

NAT1

831

276

42

58

No

1

Burkholderia dolosa AUO158

 

350701

NAT1

834

277

39

53

No

1

Burkholderia graminis C4D1M

 

396598

NAT1

837

278

37

56

No

1

Burkholderia mallei 2002721280

BURMA (2002721280)

370895

NAT1

873

290

35

51

No

1

Burkholderia mallei ATCC 10399

BURMA (ATCC 10399)

412021

NAT1

873

290

35

51

No

1

Burkholderia mallei ATCC 23344

BURMA (ATCC 23344)

243160

NAT1

873

290

35

51

No

1,2

Burkholderia mallei FMH

BURMA (FMH)

334802

NAT1

873

290

35

51

No

1

Burkholderia mallei GB8 horse 4

BURMA (GB8 horse 4)

320390

NAT1

873

290

35

51

No

1

Burkholderia mallei JHU

BURMA (JHU)

334803

NAT1

873

290

35

51

No

1

Burkholderia mallei NCTC 10229

BURM9

412022

NAT1

873

290

35

51

No

1

Burkholderia mallei NCTC 10247

BURM7

320389

NAT1

873

290

35

51

No

1

Burkholderia mallei PRL-20

BURMA (PRL-20)

436115

NAT1

873

290

35

51

No

1

Burkholderia mallei SAVP1

BURMS

320388

NAT1

873

290

35

51

No

1

Burkholderia multivorans ATCC 17616

BURM1

395019

NAT1

831

276

44

58

No

1

Burkholderia oklahomensis C6786

 

441162

NAT1

873

290

36

51

No

1

Burkholderia oklahomensis EO147

 

441163

NAT1

873

290

37

52

No

1

Burkholderia phymatum STM815

BURP8

391038

NAT1

831

276

39

56

No

1

Burkholderia phytofirmans PsJN

BURPP

398527

NAT1

840

279

41

56

No

1

Burkholderia pseudomallei 1106a

BURP0

357348

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 1106b

BURPS (1106b)

357347

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 112

BURPS (112)

441154

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 14

BURPS (14)

441160

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 1655

BURPS (1655)

331109

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 1710a

BURPS (1710a)

320371

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 1710b

BURP1

320372

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 305

BURPS (305)

425067

NAT1

873

290

35

51

No

1

Burkholderia pseudomallei 406e

BURPS (406e)

360118

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 668

BURP6

320373

NAT1

873

290

34

51

No

1

Burkholderia pseudomallei 7894

BURPS (7894)

441156

NAT1

873

290

35

51

No

1

Burkholderia pseudomallei 9

BURPS (9)

441158

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei 91

BURPS (91)

441159

NAT1

873

290

35

51

No

1

Burkholderia pseudomallei B7210

BURPS (B7210)

441155

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei BCC215

BURPS (BCC215)

441152

NAT1

873

290

35

51

No

1

Burkholderia pseudomallei DM98

BURPS (DM98)

441161

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei K96243

BURPS (K96243)

272560

NAT1

873

290

35

51

No

1,2

Burkholderia pseudomallei NCTC 13177

BURPS (NCTC 13177)

441153

NAT1

873

290

35

51

No

1

Burkholderia pseudomallei Pasteur 52237

BURPS (Pasteur 52237)

331978

NAT1

873

290

35

52

No

1

Burkholderia pseudomallei S13

BURPS (S13)

320374

NAT1

873

290

35

52

No

1

Burkholderia sp. 383

BURS3

269483

NAT1

831

276

36

52

No

1

Burkholderia thailandensis Bt4

BURTH (Bt4)

441164

NAT1

873

290

35

50

No

1

Burkholderia thailandensis E264

BURTA

271848

NAT1

873

290

35

50

No

1

Burkholderia thailandensis TXDOH

BURTH (TXDOH)

441165

NAT1

873

290

35

51

No

1

Burkholderia thailandensis MSMB 43

BURTH (MSMB 43)

441157

NAT1

870

289

35

52

No

1

Burkholderia ubonensis Bu

 

441166

NAT1

882

293

40

56

No

1

Burkholderia vietnamiensis G4

BURVG

269482

NAT1

834

277

37

53

No

1

Burkholderia xenovorans LB400

BURXL

266265

NAT1

837

278

39

54

No

1

Ralstonia eutropha H16

RALEH

381666

NAT1

867

288

34

49

No

1

Ralstonia eutropha JMP134

RALEJ

264198

NAT1

846

281

33

46

No

1,2

Ralstonia metallidurans CH34

RALME

266264

NAT1

879

292

32

45

No

1,2

Other beta-proteobacteria

Azoarcus sp. BH72

AZOSB

62928

NAT1

825

274

39

56

No

1

Delftia acidovorans SPH-1

DELAS

398578

NAT1

795

264

30

47

No

1

Nitrosomonas eutropha C91

NITEC

335283

NAT1

813

270

38

52

No

1

Gamma-proteobacteria

Enterobacteriales

Citrobacter koseri ATCC BAA-895

CITK8

290338

NAT1

846

281

80

88

Yes

1,26

Enterobacter sakazakii ATCC BAA-894

CROS8

290339

NAT1

822

273

43

57

No

1

Enterobacter sp. 638

ENT38

399742

NAT1

849

282

67

80

No

1

Escherichia albertii TW07627

 

502347

NAT1

846

281

75

86

No

1

Escherichia coli 101-1

ECOLX (101-1)

358709

NAT1

846

281

74

85

No

1

Escherichia coli 536

ECOL5

362663

NAT1

846

281

74

85

No

1,8

Escherichia coli 53638

ECOLX (53638)

344610

NAT1

846

281

74

85

No

1

Escherichia coli APEC O1

ECOK1

405955

NAT1

846

281

74

85

No

1

Escherichia coli B171

ECOLX (B171)

344601

NAT1

675

224

74

86

No

1

Escherichia coli B7A

ECOLX (B7A)

340184

NAT1

846

281

74

85

No

1

Escherichia coli C str. ATCC 8739

ECOLC

481805

NAT1

846

281

74

85

No

1

Escherichia coli CFT073

ECOLX (CFT073)

199310

NAT1

846

281

74

85

No

1,2

Escherichia coli E110019

ECOLX (E110019)

340186

NAT1

846

281

74

85

No

1

Escherichia coli E22

ECOLX (E22)

340185

NAT1

846

281

74

85

No

1

Escherichia coli E24377A

ECO24

331111

NAT1

846

281

74

85

No

1

Escherichia coli F11

ECOLX (F11)

340197

NAT1

846

281

74

84

No

1

Escherichia coli HS

ECOHS

331112

NAT1

846

281

74

85

No

1

Escherichia coli str. K-12 substr. DH10B

ECODH

316385

NAT1

846

281

74

85

Yes

1,7,13

Escherichia coli str. K-12 substr. MG1655

ECOLI (MG1655)

511145

NAT1

846

281

74

85

Yes

1,7,13,26

Escherichia coli O157:H7 EDL933

ECOL57 (EDL933)

155864

NAT1

846

281

74

85

No

1,2,8

Escherichia coli O157:H7 str. Sakai

ECOL57 (Sakai)

386585

NAT1

846

281

74

85

No

1,2,8

Escherichia coli O157:H7 str. EC 4024

ECOL57 (EC 4024)

444454

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4042

ECOL57 (EC 4042)

444449

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4045

ECOL57 (EC 4045)

444448

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4076

ECOL57 (EC 4076)

444453

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4113

ECOL57 (EC 4113)

444452

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4115

ECOL57 (EC 4115)

444450

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4196

ECOL57 (EC 4196)

444451

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4206

ECOL57 (EC 4206)

444447

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4401

ECOL57 (EC 4401)

478004

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4486

ECOL57 (EC 4486)

478005

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 4501

ECOL57 (EC 4501)

478006

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 508

ECOL57 (EC 508)

478007

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. EC 869

ECOL57 (EC 869)

478008

NAT1

846

281

73

85

No

1

Escherichia coli O157:H7 str. TW 14588

ECOL57 (TW 14588)

502346

NAT1

846

281

73

85

No

1

Escherichia coli SECEC SMS-3-5

ECOSM

439855

NAT1

846

281

75

85

No

1

Escherichia coli UTI89

ECOUT

364106

NAT1

846

281

74

85

No

1

Escherichia coli str. K-12 substr. W3110

ECOW3

316407

NAT1

846

281

74

85

Yes

1,2,7,13

Klebsiella pneumoniae subsp. pneumoniae MGH78578

KLEP7

272620

NAT1

846

281

73

83

Yes

1,7,26,27

Salmonella enterica subsp. enterica serovar 4,[5],12:i:- str. CVM23701

SALET (4,[5],12:i:- CVM23701)

440534

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Agona str. SL483

SALET (Agona SL483

454166

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853

SALDC

439851

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Hadar str. RI_05P066

SALHA

465516

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Heidelberg str. SL476

SALHS

454169

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Heidelberg str. SL486

SALET (Heidelberg SL486)

454164

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Javiana str. GA_MM04042433

SALET (Javiana GA_MM04042433)

454167

NAT1

846

281

99

100

No

1

Salmonella enterica subsp. enterica serovar Kentucky str. CDC 191

SALET (Kentucky CDC 191)

454231

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188

SALET (Kentucky CVM29188)

439842

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Newport str. SL254

SALNS

423368

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Newport str. SL317

SALNE (SL317)

454168

NAT1

846

281

99

99

No

1

Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150

SALPA (ATCC 9150)

295319

NAT1

846

281

98

100

No

1,7

Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7

SALPB

272994

NAT1

846

281

99

100

No

1

Salmonella enterica subsp. enterica serovar Saintpaul str. SARA23

SALET (Saintpaul SARA23)

439846

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Saintpaul str. SARA29

SALET (Saintpaul SARA29)

439847

NAT1

846

281

98

98

No

1

Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633

SALSV

439843

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Schwarzengrund str. SL480

SALET (Schwarzengrund SL480)

454165

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Typhi Ty2

SALET (Typhi Ty2)

209261

NAT1

846

281

98

99

No

1,2

Salmonella enterica subsp. enterica serovar Typhi str. CT18

SALET (Typhi CT18)

220341

NAT1

846

281

98

99

No

1,7,8

Salmonella enterica subsp. enterica serovar Virchow str. SL491

SALVI (SL491)

465517

NAT1

846

281

100

100

No

1

Salmonella enterica subsp. enterica serovar Weltevreden str. HI_N05-537

SALET (Weltevreden)

465518

NAT1

846

281

99

99

No

1

Salmonella typhimurium LT2

SALTY (LT2)

99287

NAT1

846

281

100

100

Yes

1,2,7,8,13,26,28-30

Serratia proteamaculans 568

SERP5

399741

NAT1

762

253

34

54

No

1

Shigella sonnei Ss046

SHISS

300269

NAT1

846

281

74

85

No

1

Pseudomonadaceae

Pseudomonas fluorescens PfO-1

PSEPF

205922

NAT1

828

275

40

57

No

1,2,21

Pseudomonas fluorescens Pf-5

PSEF5

220664

NAT1

807

268

38

55

No

1,21

Pseudomonas aeruginosa PACS2

PSEAE (PACS2)

388272

NAT1

840

279

31

48

No

1

Pseudomonas aeruginosa 2192

PSEAE (2192)

350703

NAT1

840

279

31

47

No

1

Pseudomonas aeruginosa C3719

PSEAE (C3719)

350704

NAT1

840

279

31

47

No

1

Pseudomonas aeruginosa UCBPP-PA14

PSEAB

208963

NAT1

840

279

31

47

No

1,2

Pseudomonas aeruginosa PAO1

PSEAE (PAO1)

208964

NAT1

840

279

31

47

Yes

1,2,7,8,26,31,32

Pseudomonas aeruginosa PA7

PSEA7

381754

NAT1

840

279

31

47

No

1

Pseudomonas mendocina ymp

PSEMY

399739

NAT1

828

275

38

55

No

1

Vibrionaceae

Photobacterium sp. SKA34

 

121723

NAT1

804

267

32

50

No

1

Vibrio alginolyticus 12G01

VIBAL (12G01)

314288

NAT1

807

268

32

50

No

1

Vibrio angustum S14

PHOAS

314292

NAT1

804

267

31

48

No

1

Vibrio shilonii AK1

 

391591

NAT1

798

265

33

55

No

1

Vibrio parahaemolyticus AQ3810

VIBPA (AQ3810)

419109

NAT1

807

268

32

50

No

1,8

Vibrio sp. Ex25

VIBSE

150340

NAT1

807

268

32

50

No

1

Vibrio parahaemolyticus RIMD 2210633

VIBPA (RIMD 2210633)

223926

NAT1

807

268

32

50

No

1,2,8

Vibrio harveyi ATCC BAA-1116

VIBHB

338187

NAT1

816

271

34

49

No

1

Vibrio harveyi HY01

VIBHA (HY01)

410291

NAT1

816

271

32

49

No

1

Xanthomonadaceae

Stenotrophomonas maltophilia R551-3

STRM5

391008

NAT1

1044

347

37

52

No

1

Other gamma-proteobacteria

Colwellia psychrerythrea 34H

COLP3

167879

NAT1

822

273

30

50

No

1

Hahella chejuensis KCTC 2396

HAHCH

349521

NAT1

816

271

34

53

No

1

Legionella pneumophila str. Corby

LEGPC

400673

NAT1

969

322

25

46

No

1,35

Legionella pneumophila subsp. pneumophila str. Philadelphia 1

LEGPH

272624

NAT1

969

322

25

47

No

1,2,7,35

Legionella pneumophila str. Paris

LEGPA

297246

NAT1

969

322

25

47

No

1,2,35

Legionella pneumophila str. Lens

LEGPL

297245

NAT1

969

322

25

46

No

1,2,35

Nitrococcus mobilis Nb-231

 

314278

NAT1

825

274

38

53

No

1

Marinomonas sp. MWYL1

MARMS

400668

NAT1

846

281

27

46

No

1

Marinomonas sp. MED121

 

314277

NAT1

855

284

27

46

No

1

Pseudoalteromonas tunicata D2

 

87626

NAT1

819

272

30

51

No

1

Psychrobacter sp. PRwf-1

PSYWF

349106

NAT1

831

276

24

46

No

1

Saccharophagus degradans 2-40

SACD2

203122

NAT1

801

266

31

49

No

1

Vibrionales bacterium SWAT-3

 

391574

NAT1

792

263

35

53

No

1

Delta-proteobacteria

Myxococcus xanthus DK 1622

MYXXD

246197

NAT1

756

251

36

49

No

1

Geobacter bemidjiensis Bem

GEOBB

404380

NAT1

798

265

33

50

No

1

Geobacter lovleyi SZ

GEOLS

398767

NAT1

804

267

33

46

No

1

Pelobacter propionicus DSM 2379

PELPD

338966

NAT1

807

268

32

49

No

1

Plesiocystis pacifica SIR-1

 

391625

NAT1

2268

755

34

42

No

1

OTHER BACTERIA

Chloroflexus aurantiacus J-10-fl

CHLAA

324602

NAT1

813

270

31

48

No

1,2

Footnotes

(a)         Data is updated by the manager of the website, or whenever external submissions of novel prokaryotic NAT genes are received. We encourage colleagues to also contact us if they wish to suggest any amendments to the current dataset.

(b)         Official organism scientific names, identification codes and taxonomy identifiers are from the UniProt Taxonomy Browser. Taxonomic presentation is according to the NCBI Taxonomy Database, which provides a platform for the classification of all organisms represented in the GenBank database. Please note that these databases are not a primary source for taxonomic or phylogenetic information and should not be used as such.

(c)         The gene symbols are assigned according to the official guidelines of the NAT Gene Nomenclature Committee. Older unofficial symbols used to describe NAT loci (e.g. OAT, AAC etc.) have been withdrawn and are not cited in this webpage.

(d)         Abbreviations: ORF – open reading frame; bp – base pairs; aa – amino acids.

(e)         Amino acid sequence homology (identity and similarity) is calculated relative to the prokaryotic NAT reference sequence, i.e. the NAT1 protein of Salmonella typhimurium LT2 [(SALTY)NAT1 (LT2) protein with accession no. BAA14331].

(f)          NAT-like sequences with frameshift mutations that are not attributed to sequencing errors. The mutations were corrected in order to reconstruct and translate the hypothetical open reading frame of these putative pseudogenes.

 

All reported sequences are stored in electronic format and can be requested from the manager of this website. Please note that many of the ORFs described in the above table were reconstructed from partial low-homology genomic sequences, retrieved during our database searches. Therefore, these sequences represent only putative NAT genes and each ORF should be checked for possible inaccuracies in length and sequence before any further study is undertaken.

 

The set of annotated NAT genes on this page is also presented in:

Vagena, E.; Fakis, G. and Boukouvala, S. (2008) Arylamine N-acetyltransferases in prokaryotic and eukaryotic genomes: A survey of public databases. Curr. Drug Metab. 9(7), 628-660.

Glenn, A.E.; Karagianni E.P.; Ulndreaj, A. and Boukouvala, S. (2010) Comparative genomic and phylogenetic investigation of the xenobiotic metabolizing arylamine N-acetyltransferase enzyme family. FEBS Lett. 584(14), 3158-3164.

 

If you wish to acknowledge this website as a source of data in future publications, please cite reference:

Vagena, E.; Fakis, G. and Boukouvala, S. (2008) Arylamine N-acetyltransferases in prokaryotic and eukaryotic genomes: A survey of public databases. Curr. Drug Metab. 9(7), 628-660.

 

For new submissions or enquiries, please contact Dr. Sotiria Boukouvala (sboukouv@mbg.duth.gr).

 

 

Back

 

Literature

[1]     Vagena, E.; Fakis, G. and Boukouvala, S. (2008) Arylamine N-acetyltransferases in prokaryotic and eukaryotic genomes: A survey of public databases. Curr. Drug Metab. 9(7), 628-660.

[2]     Boukouvala, S. and Fakis, G. (2005) Arylamine N-acetyltransferases: what we learn from genes and genomes. Drug Metab. Rev. 37(3), 511-564.

[3]     August, P.R.; Tang, L.; Yoon, Y.J.; Ning, S.; Müller, R.; Yu, T.W.; Taylor, M.; Hoffmann, D.; Kim, C.G.; Zhang, X.; Hutchinson, C.R. and Floss, H.G. (1998) Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem. Biol. 5(20), 69-79.

[4]     Schupp, T.; Toupet, C.; Engel, N. and Goff, S. (1998) Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei. FEMS Microbiol. Lett. 159(2), 201-207.

[5]     Yu, T.W.; Shen, Y.; Doi-Katayama, Y.; Tang, L.; Park, C.; Moore, B.S.; Hutchinson, R.C. and Floss, H.G. (1999) Direct evidence that the rifamycin polyketide synthase assembles polyketide chains progressively. Proc. Natl. Acad. Sci. USA 96(16), 9051-9056.

[6]     Pompeo, F.; Mushtaq, A. and Sim, E. (2002) Expression and purification of the rifamycin amide synthase, RifF, an enzyme homologous to the prokaryotic arylamine N-acetyltransferases. Protein Expr. Purif. 24(1), 138-151.

[7]     Payton, M.; Mushtaq, A.; Yu, T.W.; Wu, L.J.; Sinclair, J. and Sim, E. (2001) Eubacterial arylamine N-acetyltransferases - identification and comparison of 18 members of the protein family with conserved active site cysteine, histidine and aspartate residues. Microbiology 147(Pt. 5), 1137-1147.

[8]     Sandy, J.; Mushtaq, A.; Holton, S.J.; Schartau, P.; Noble, M.E.M. and Sim, E. (2005) Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines. Biochem. J. 390(Pt. 1), 115-123.

[9]     Upton, A.M; Mushtaq, A.; Victor, T.C.; Sampson, S.L.; Sandy, J.; Smith, D.M.; van Helden, P.V. and Sim, E. (2001) Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol. Microbiol. 42(2), 309-317.

[10]    Bhakta, S.; Besra, G.S.; Upton, A.M.; Parish, T.; Sholto-Douglas-Vernon, C.; Gibson, K.J.C.; Knutton, S.; Gordon, S.; daSilva, R.P.; Anderton, M.C. and Sim, E. (2004) Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J. Exp. Med. 199(9), 1191-1199.

[11]    Anderton, M.C.; Bhakta, S.; Besra, G.S.; Jeavons, P.; Eltis, L.D. and Sim, E. (2006) Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG. Mol. Microbiol. 59(1), 181-192.

[12]    Fullam, E.; Westwood, I.M.; Anderton, M.C.; Lowe, E.D.; Sim, E. and Noble, M.E.M. (2008) Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase. J. Mol. Biol. 375(1), 178-191.

[13]    Payton, M.; Auty, R.; Delgoda, R.; Everett, M. and Sim, E. (1999) Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance. J. Bacteriol. 181(4), 1343-1347.

[14]    Payton, M.; Gifford, C.; Schartau, P.; Hagemeier, C.; Mushtaq, A.; Lucas, S.; Pinter, K. and Sim, E. (2001) Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis. Microbiology 147(12), 3295-3302.

[15]    Sandy, J.; Mushtaq, A.; Kawamura, A.; Sinclair, J.; Sim, E. and Noble, M. (2002) The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis – an enzyme which inactivates the anti-tubercular drug, isoniazid. J. Mol. Biol. 318(4), 1071-1083.

[16]    Sandy, J.; Holton, S.; Fullam, E.; Sim, E. and Noble, M. (2005) Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein Sci. 14(3), 775-782.

[17]    Van der Geize, R.; Yam, K.; Heuser, T.; Wilbrink, M.H.; Hara, H.; Anderton, M.C.; Sim, E.; Dijkhuizen, L.; Davies, J.E.; Mohn, W.W. and Eltis, L.D. (2007) A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages Proc. Natl. Acad. Sci. USA 104(6), 1947-1952.

[18]    Suzuki, H.; Ohnishi, Y. and Horinouchi, S. (2007) Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus. J. Bacteriol. 189(5), 2155-2159.

[19]    Pluvinage, B.; Dairou, J.; Possot, O.M.; Martins, M.; Fouet, A.; Dupret, J.M. and Rodrigues-Lima, F. (2007) Cloning and molecular characterization of three arylamine N-acetyltransferase genes from Bacillus anthracis: identification of unusual enzymatic properties and their contribution to sulfamethoxazole resistance. Biochemistry 46(23), 7069-7078.

[20]    Pluvinage, B.; de la Sierra-Gallay, I.L.; Martins, M.; Ragunathan, N.; Dupret, J.M. and Rodrigues-Lima, F. (2007) Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis. Acta Crystallogr. F63(Pt. 10), 862-864.

[21]    Rodrigues-Lima, F. and Dupret, J.M. (2002) In silico sequence analysis of arylamine N-acetyltransferases: evidence for an absence of lateral gene transfer from bacteria to vertebrates and first description of paralogs in bacteria. Biochem. Biophys. Res. Commun. 293(2), 783-792.

[22]    Holton, S.J.; Dairou, J.; Sandy, J.; Rodrigues-Lima, F.; Dupret, J.M.; Noble, M.E.M. and Sim, E. (2005) Structure of Mesorhizobium loti arylamine N-acetyltransferase 1. Acta Crystallogr. F61(Pt. 1), 14-16.

[23]    Rodrigues-Lima, F.; Dairou, J.; Diaz, C.L.; Rubio, M.C.; Sim, E.; Spaink, H.P. and Dupret, J.M. (2006) Cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway. Mol. Microbiol. 60(2), 505-512.

[24]    Dairou, J.; Flatters, D.; Chaffotte, A.F.; Pluvinage, B.; Sim, E.; Dupret, J.M. and Rodrigues-Lima, F. (2006) Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): a biochemical and computational study. FEBS Lett. 580(7), 1780-1788.

[25]    Atmane, N.; Dairou, J.; Flatters, D.; Martins, M.; Pluvinage, B.; Derreumaux, P.; Dupret, J.M. and Rodrigues-Lima, F. (2007) The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1. Biochem. Biophys. Res. Commun. 361(1), 256-262.

[26]    Deloménie, C.; Fouix, S.; Longuemaux, S.; Brahimi, N.; Bizet, C.; Picard, B.; Denamur, E. and Dupret, J.M. (2001) Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J. Bacteriol. 183(11), 3417-3427.

[27]    Chung, J.G; Lo, H.H.; Hsieh, S.E. and Yen, Y.S. (1997) Ibuprofen inhibits arylamine N-acetyltransferase activity in the bacteria Klebsiella pneumoniae. Curr. Microbiol. 35(4), 195-200.

[28]    Watanabe, M.; Sofuni, T. and Nohmi, T. (1992) Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms. J. Biol. Chem. 267(12), 8429-8436.

[29]    Sinclair, J.C.; Sandy, J.; Delgoda, R.; Sim, E. and Noble, M.E.M. (2000) Structure of arylamine N-acetyltransferase reveals a catalytic triad. Nat. Struct. Biol. 7(7), 560-564.

[30]    Mushtaq, A.; Payton, M. and Sim, E. (2002) The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity. J. Biol. Chem. 277(14), 12175-12181.

[31]    Westwood, I.M.; Holton, S.J.; Rodrigues-Lima, F.; Dupret, J.M.; Bhakta, S.; Noble, M.E.M. and Sim, E. (2005) Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. Biochem. J. 385(Pt. 2), 605-612.

[32]    Westwood, I.M. and Sim, E. (2007) Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa. BMC Biochem. 8(3), published online.

[33]    Glenn, A.E.; Karagianni, E.P.; Ulndreaj, A. and Boukouvala, S. (2010) Comparative genomic and phylogenetic investigation of the xenobiotic metabolizing arylamine N-acetyltransferase enzyme family. FEBS Lett. 584(14), 3158-3164.

[34]    Martins, M.; Pluvinage, B.; Li de la Sierra-Gallay, I.; Barabault, F.; Dairou, J.; Dupret, J.M. and Rodrigues-Lima, F. (2008) Functional and structural characterization of the arylamine N-acetyltransferase from the opportunistic pathogen Nocardia farcinica. J. Mol. Biol. 383(3), 549-560.

[35]     Kubiak, X.; Dervins-Ravault, D.; Pluvinage, B.; Chaffotte, A.F.; Gomez-Valero, L.; Dairou, J.; Busi, F.; Dupret, J.M.; Buchrieser, C. and Rodrigues-Lima, F. (2012) Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila. Biochem. J. 445(2), 219-228.

 

 

Back